N IIP, glucose exhibited an ultradian pattern with peaks at 10:00 and


N IIP, glucose exhibited an ultradian pattern with peaks at 10:00 and 19:00 hours, and was lower in the early morning than during the remainder of the day. Consideration of this ultradian variation may avoid hypoglycemic and hyperglycemic episodes and so facilitateP114 Continuous monitoring of blood parameters in intensive care patientsA Weinstein1, O Herzenstein1, E Gabis1, I Kagan2, P Singer2 1Orsense Ltd, Nes Ziona, Israel; 2Rabin Medical Center, Petah Tikva, Israel Critical Care 2009, 13(Suppl 1):P114 (doi: 10.1186/cc7278) Introduction Monitoring of blood parameters, such as glucose, hemoglobin and oxygen saturation, is essential in critically ill patients. The current invasive methods are not frequent enough for efficient tight glycemic control, and result in a high rate of Triazavirin hypoglycemia. In addition, there is a growing need for a continuous hemoglobin measurement in postoperative care units and ICUs. The purpose of this study is to evaluate the feasibility of the fully noninvasive blood monitor (NBM device; OrSense Ltd, Nes Ziona, Israel) for continuous monitoring of glucose, hemoglobin and oxygen saturation in critically ill patients. Methods The study was conducted on 14 patients (seven female, seven male, ages 34 to 92 years) in the ICU of the Rabin Medical Center, upon receipt of informed consent. The NBM probe wasSAvailable online http://ccforum.com/supplements/13/Sbetter glucose control with an IIP. Studies targeting control of hyperglycemia should report mean blood glucose values for the entire day rather than early morning values. References 1. Dellinger RP, et al.: Intensive Care Med 2004, 30:536-555. 2. Smith SM, et al.: Diabetes Care 2007, 30:2503-2505.Table 1 (abstract P117) Time (min) 120 240 360 540 Syringe concentration (units/100 ml) 67.2 68.1 63.3 52.9 Burette concentration (units/100 ml) 52.4 44 41.2 18.P116 Hypoglycaemia is associated with a higher mortality in critically ill patientsA Jose Pereira1, A Biasi Cavalcanti1, F Pereira Almeida1, T Correa1, J Telles2, M Lobato1, D Nishimura1, R Da Hora Passos1, E Silva1 1Hospital Israelita Albert Einstein, S Paulo, Brazil; 2Hospital Portugues, Salvador, Brazil Critical Care 2009, 13(Suppl 1):P116 (doi: 10.1186/cc7280) Introduction Hypoglycaemia, a common complication of strict glucose control in critically ill patients, has controversial effects on mortality. The hyperglycaemic index (HGI) takes into account the unequal time distribution of blood glucose sampling and is a better predictor of death than other methods PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/2825712 to quantify hyperglycaemia [1]. By analogy with the HGI, we defined the hypoglycaemic index (HGI-60) as the area above the glucose curve and lower than 60 mg/dl divided by the length of ICU stay. The objective of the study was to evaluate the effects of hypoglycaemia on inhospital mortality in critical care patients using a new method for quantification of hypoglycaemia, the hypoglycaemic index (HGI-60). Methods A retrospective study performed in four mixed ICUs. From 2004 through 2006, patients treated with continuous insulin therapy were included. Admission type, sex, age, the occurrence of hypoglycaemia <60 mg/dl, APACHE II score and outcome (hospital dead) were recorded. The HGI-60 is calculated after simple interpolation of all glucose values measured during the ICU stay. The relations between independent variables and hospital mortality were determined by logistic regression analysis. Results One hundred and ninety-six patients were included. The mea.