The SVD examination and helped draft the manuscript. CHS helped with


The 1-Oleoyl lysophosphatidic acid SVD evaluation and aided draft the manuscript. CHS served with presenting the outcome, provided suggestions on its evaluation and aided draft the manuscript. MMS served draft the manuscript and furnished guidance on examining the final results. WM participated within the coordination from the research and served draft the manuscript. All authors read through and accredited the ultimate manuscript. Competing passions The authors declare which they haven’t any competing passions. Posted: PubMed ID: 22 December 2011 References one. Consortium TU: The Common Protein Resource (UniProt) in 2010. Nucleic Acids Analysis 2010, 38(Database difficulty):D142-D148. 2. Finn RD, Mistry J, Coggill P, Heger A, Pollington J, Gavin OL, Gunasekaran P, Ceric G, Forslund K, Holm L, Sohhhammer ELL, Eddy SR, Bateman A: The Pfam protein families databases. Nucleic Acids Exploration 2010, 38(Databases concern):D211-D222. three. Murzin AG, Brenner SE, Hubbard T, Chothia C: SCOP: a structural classification of proteins database with the investigation of sequences and structures. Journal of Molecular Biology 1995, 247(four):536-40. four. Berman HM, Battistuz T, Bhat TN, Bluhm WF, Bourne PE, Burkhardt K, Feng Z, Gilliland GL, Iype L, Jain S, Fagan P, Marvin J, Padilla D, Ravichandran V, Schneider B, Thanki N, Weissig H, Westbrook JD, Zardecki C: The Protein Knowledge Bank. Acta Crystallogr D Biol Crystallogr 2002, fifty eight(Pt 6 No 1):899-907. five. Laskowski RA, Watson JD, Thornton JM: Protein perform prediction making use of nearby 3D templates. Journal of Molecular Biology 2005, 351(3):614-626. 6. Laskowski RA, Watson JD, Thornton JM: ProFunc: a server for predicting protein function from 3D structure. Nucleic Acids Investigate 2005, 33(Internet Server situation):W89-93. seven. Watson JD, Roman AL, Thornton JM: Predicting protein functionality from sequence and structural knowledge. Present-day Viewpoint in Structural Biology 2005, 15(3):275-284. eight. Watson JD, Sanderson S, Ezersky A, Savchenko A, Edwards A, Orengo C, Joachimiak A, Laskowski RA, Thornton JM: Toward thoroughly automated structure-based function prediction in structural genomics: a situation study. Journal of Molecular Biology 2007, 367(five):1511-1522. 9. Chothia C, Lesk AM: The relation between the divergence of sequence and structure in proteins. EMBO J 1986, five(four):823-6. ten. Ding CH, Dubchak I: Multi-class protein fold recognition applying assistance vector equipment and neural networks. Bioinformatics 2001, seventeen(4):349-58. 11. Shen HB, Chou KC: Ensemble classifier for protein fold pattern recognition. Bioinformatics 2006, 22(fourteen):1717-22. twelve. Cheng J, Baldi P: A device learning info retrieval solution to protein fold recognition. Bioinformatics 2006, 22(12):1456-63. thirteen. Barker JA, Thornton JM: An algorithm for constraint-based structural template matching: application to 3D templates with statistical analysis. Bioinformatics 2003, 19(thirteen):1644-9. fourteen. Goyal K, Mohanty D, Mande SC: PAR-3D: a server to predict protein active web site residues. Nucleic Acids Analysis 2007, 35(Net Server challenge):W503-5.15. Stark A, Russell RB: Annotation in three dimensions. PINTS: Patterns in Non-homologous Tertiary Constructions. Nucleic Acids Exploration 2003, 31(thirteen):3341-4. sixteen. Shazman S, Celniker G, Haber O, Glaser F, Mandel-Gutfreund Y: Patch Finder Additionally (PFplus): a web server for extracting and exhibiting constructive electrostatic patches on protein surfaces. Nucleic Acids Investigation 2007, 35(Website Server problem):W526-30. seventeen. Babor M, Gerzon S, Raveh B, Sobolev V, Edelman M: Prediction of transition metal-binding sites from apo protein structures. Proteins 2008,.